Below are select publications co-authored by our scientific founder, J. Christopher Love, Ph.D.
Dr. Love is Enumeral's scientific founder and is an Associate Professor in the Department of Chemical Engineering at the Massachusetts Institute of Technology and an associate member at the Eli and Edythe L. Broad Institute. He began work on a number of the unconventional methods to fabricate micro- and nano-scale structures using both soft lithography and self-assembly that are foundational to Enumeral’s technology platform while in the laboratory of George Whitesides at Harvard.
Dr. Love extended his research into immunology and pathology when he was a research fellow at Harvard Medical School and then as an Instructor at the Immune Disease Institute (formerly CBRI). Drawing on his expertise in surface chemistry and microtechnologies, he studied both the dynamics of phagosomal maturation in dendritic cells and the activation of naïve B cells by live cell imaging and microfluidics. Dr. Love earned his Ph.D. in physical chemistry at Harvard University and B.S. in chemistry from University of Virginia.
- Lohr, J.G., et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nature Biotechnology. 2014; 32(5):479-84.
- Chattopadhyay, P.K., et al. Single-cell technologies for monitoring immune systems. Nature Immunology. 2014; 15(2):128-35.
- Zhou, P. and Shaffer, D.R., et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. 2014; 506(7486):52-7.
- Adalsteinsson, V., et al. Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines. Integrative Biology. 2013; 5(10):1272-81.
- Varadarajan, N., et al. A high-throughput single-cell analysis of human CD8+ T Cell functions reveals discordance for cytokine secretion and cytolysis. The Journal of Clinical Investigation. 2011; 121(11):4322-31.
- Han, Q., et al. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab on a Chip. 2010; 10(11):1391-400.
- Story, C.M., et al. Profiling antibody responses by multiparametric analysis of primary B cells. Proceedings of the National Academy of Sciences. 2008; 105(46):17902-7.
- Bradshaw, E.M., et al. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology. 2008; 129(1):10-8.
- Love, J.C., et al. A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nature Biotechnology. 24(6):703-7.